WARRINGTON, PA — Windtree Therapeutics, Inc. has announced a new patent application for istaroxime derivatives, aimed at preventing or reducing the risk of acute myocardial arrhythmia. The filing builds on encouraging results from preclinical animal studies and clinical trials in acute heart failure (AHF) and early cardiogenic shock (ECS).
The company’s research has demonstrated that istaroxime and its metabolite derivatives hold promise in improving cardiac function while minimizing the risk of arrhythmias, irregular heartbeats that can impact the heart’s ability to pump blood effectively. Ventricular arrhythmias, in particular, are life-threatening and a key concern in heart failure treatments.
“In our Phase 2 clinical program, we have not seen an increase in clinically significant cardiac arrhythmias in istaroxime treated patients while improving heart function and blood pressure,” said Dr. Steve Simonson, Chief Medical Officer and Senior Vice President at Windtree. “We believe this characteristic may be related to SERCA2a activation by istaroxime and it has the potential to differentiate istaroxime from current drug treatments for cardiogenic shock and AHF including inotropes and vasopressors.”
The new patent application highlights how istaroxime-related advancements could address critical risks, such as arrhythmias caused by underlying cardiac conditions or existing treatments like catecholamines. According to Windtree, these developments represent a significant step in improving patient outcomes while safeguarding heart rhythm stability during treatment.
Dr. Simonson added, “With the results of our clinical program thus far and the additional animal model data, we determined there are unique aspects that warrant filing for intellectual property protection.”
If successful, the istaroxime derivatives could provide an innovative therapeutic option for patients with ischemia and cardiac conditions needing enhanced heart function, potentially setting a new standard in treating acute cardiac challenges.
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