CHADDS FORD, PA — MOBILion Systems, Inc. is set to take center stage at the 21st Annual US HUPO Conference in Philadelphia, PA, from February 22-26, 2025. Known for its commitment to pushing the boundaries of separation science, the company will showcase its latest innovation, the Parallel Accumulation with Mobility Aligned Fragmentation (PAMAF) operating mode, through a series of scientific presentations.
Revolutionizing Proteomics with PAMAF
PAMAF represents a significant advancement in liquid chromatography-mass spectrometry (LC-MS) applications, delivering improved speed, sensitivity, and precision for proteomics research. Replacing the conventional quadrupole isolation step with high-resolution ion mobility separation, this technology enables fragmentation data with up to 10 times higher signal-to-noise ratios and operates at speeds approximately five times faster than traditional methods. Additionally, PAMAF utilizes nearly 100% of ions, proving invaluable for workflows with small sample sizes, such as single-cell proteomics.
Dr. Melissa Sherman, CEO of MOBILion Systems, emphasized PAMAF’s impact on critical areas of human health research. “Our PAMAF operating mode enables researchers to make more accurate analytical measurements and achieve deeper proteome characterization,” she said. “By optimizing ion utilization, PAMAF supports sample-limited workflows while providing unmatched precision.”
Scientific Highlights
At the conference, MOBILion will present the results of applying PAMAF to complex proteomics workflows. Researchers will demonstrate how the technology reduces chimeric spectra, improving protein quantification and post-translational modification analysis.
Some highlights from the scientific program include:
- Oral Presentation (February 25): Dr. Daniel DeBord, Chief Technology Officer at MOBILion, will discuss abandoning the quadrupole for MS fragmentation at 1,000 Hz speeds with 100% ion utilization.
- Posters (February 24-25): Topics range from evaluating PAMAF’s performance in proteomics to its role in streamlining high-throughput targeted analysis.
CKD Research Feature
Among the most anticipated sessions is an educational breakfast seminar on February 26, where Prof. Birgit Schilling of The Buck Institute for Research on Aging will present groundbreaking research into succinylation levels in a sirtuin-5 knockout mouse model for chronic kidney disease (CKD). Using MOBILion’s PAMAF platform, her team identified hundreds of succinylation sites potentially linked to protective phenotypes in kidney diseases, underscoring the role of next-generation proteomics tools in advancing biomedical discovery.
Advancing the Proteomics Frontier
Visitors can engage with MOBILion representatives at booth 18 to explore how PAMAF is shaping the future of proteomics research. By addressing longstanding challenges in proteome analysis, including speed and sensitivity, MOBILion continues to set new industry standards.
Looking ahead, MOBILion’s advancements signal a promising future for proteomics, where innovative tools unlock deeper insights into health and disease. With PAMAF, the company is poised to redefine workflows while empowering researchers to tackle complex biological questions with unprecedented precision.
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