CHADDS FORD, PA — MOBILion Systems, Inc. has introduced a groundbreaking approach to mass spectrometry that promises to transform complex sample analysis in proteomics, lipidomics, and metabolomics. The firm’s innovative use of Structures for Lossless Ion Manipulation (SLIM)-based High-Resolution Ion Mobility (HRIM) technology aims to provide unprecedented speed, sensitivity, and accuracy in these fields.
Announced in a detailed white paper, the new method abandons traditional quadrupole isolation in favor of more efficient and precise mobility separation. This shift is expected to enhance throughput, allowing for a fivefold increase in sample analysis speed and significantly improved detection of low-abundance signals.
“This is a pivotal development for MOBILion,” said Melissa Sherman, Ph.D., CEO of MOBILion Systems. “Our new approach replaces slow, inefficient quadrupole isolation with high-resolution mobility separation, offering unmatched speed and peak capacity. This represents a paradigm shift in mass spectrometry and opens doors to new scientific discoveries.”
The breakthrough, termed Parallel Accumulation with Mobility Aligned Fragmentation (PAMAF), enables simultaneous processing of all analyte precursors, overcoming sensitivity limitations of traditional methods. “PAMAF removes the slow and inefficient quadrupole from the workflow, resulting in tenfold higher signal-to-noise ratios at speeds five times faster than current systems,” explained Daniel DeBord, Ph.D., Chief Technology Officer at MOBILion.
This advancement has significant implications for large-scale studies, allowing researchers to analyze more samples in less time. The PAMAF method generates fragmentation spectra at speeds up to 1,000 Hz, greatly surpassing the current industry standard of 200 Hz.
Moreover, the technology enhances the detection of low-abundance signals in complex samples such as biological fluids, capturing nearly 100% of the ion signal. This capability offers a substantial improvement in sensitivity over conventional techniques, which typically capture only about 0.5% of available signals.
Sherman emphasized the long-term impact of this innovation, stating, “Seismic changes in mass spectrometry’s fundamental operational modes are rare. We believe our technology represents the beginning of the next 15 to 20 years of product development, promising unprecedented performance in speed, sensitivity, and specificity.”
With this new approach, MOBILion Systems positions itself at the forefront of mass spectrometry, potentially enabling new experiments and insights in proteomics research that were previously impractical or impossible.
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