DOYLESTOWN, PA — Mid-Atlantic BioTherapeutics (MABT) and Accelero Biostructures have entered a research collaboration aimed at developing novel USP30 inhibitors. These inhibitors target neurological disorders such as Alzheimer’s and Parkinson’s Diseases, offering potential clinical breakthroughs.
Accelero will leverage its proprietary ABS-OneStepSM platform, which integrates high-throughput protein X-ray crystallography with machine learning and artificial intelligence, to identify promising compounds. This advanced technology employs computational chemistry to enhance the drug discovery process. MABT will manage the preclinical testing phase and oversee the further development of these compounds.
David Horn, M.D., CEO of MABT, emphasized the potential of USP30 as a target, stating, “USP30 is an exciting, emerging target that, once effectively modulated, may have a meaningful clinical impact on several neurological disorders like Alzheimer’s and Parkinson’s Diseases, as well as a range of other medical targets.”
Debanu Das, Ph.D., Co-Founder and CEO of Accelero, expressed confidence in the partnership, adding, “Our partnership with MABT further validates the promise of our ABS-OneStep platform to discover novel chemical matter that targets promising proteins like USP30.”
This collaboration marks a significant step in the quest to address pressing medical conditions through cutting-edge research and development. The innovative approach adopted by MABT and Accelero aims to accelerate the discovery of effective treatments for challenging neurological disorders.
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