PHILADELPHIA, PA — Century Therapeutics (NASDAQ: IPSC) is set to showcase groundbreaking advancements in its iPSC-derived cell therapy platform at the upcoming 2024 ASH Annual Meeting in San Diego, from December 7-10. The company will unveil five posters highlighting significant preclinical data, underscoring its innovative approach to treating cancer and autoimmune diseases.
Chad Cowan, Ph.D., Chief Scientific Officer at Century Therapeutics, expressed enthusiasm about the developments, stating, “We are pleased to spotlight continued achievement across our pre-clinical pipeline as we develop a diverse portfolio of iNK, γδ iT, and αβ iT-cell programs spanning oncology and autoimmune diseases.” Cowan emphasized the potential of the first iPSC-derived CD4+ and CD8+ CAR T cells to function comparably to primary αβ CAR-T cells, showcasing the engineerability of iPSC-derived immune effector cells.
Among the highlighted innovations is the Allo-Evasion™ technology, using a novel CD300a TASR for universal protection against NK cells, and advanced CAR endo-domains that enhance cytotoxicity and persistence. Additionally, differentiation-stage-specific promoters allow for precise gene expression control, enhancing the engineering of immune cells for cancer immunotherapy.
One poster will discuss the successful generation of iPSC-derived CD4+ and CD8+ CAR T cells, showcasing antigen-dependent expansion and IL-2 production. Another will explore universal cloaking of allogeneic T cell therapies against NK cells via CD300a agonism. Further presentations will delve into optimizing CAR endodomains, leveraging stage-specific promoters, and the potent preclinical activity of engineered NK and γδ T cells in treating B cell-mediated autoimmune diseases.
These presentations highlight the transformative potential of Century’s iPSC-derived cell therapies, reinforcing their commitment to pioneering treatments across multiple medical indications. The detailed posters will be accessible for download after their presentation on Century Therapeutics’ Scientific Resources page.
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