RADNOR, PA — NRx Pharmaceuticals, Inc. (Nasdaq: NRXP), in collaboration with Nephron Pharmaceuticals, has announced the development of a novel formulation of IV Ketamine, known as HTX-100, that achieves a neutral pH. This innovative advancement contrasts sharply with the acidic nature of existing generic ketamine formulations, which can cause pain and potentially lead to skin ulcers when administered subcutaneously.
The introduction of HTX-100 marks a significant leap forward in ketamine therapy, offering a patentable solution that could pave the way for its administration through insulin pump-like devices in clinical settings. This method would notably bypass the need for personnel specialized in intravenous infusions, simplifying the treatment process for patients.
NRx’s groundbreaking formulation is expected to secure one or more patents, encompassing composition of matter or formulation patents, underscoring the uniqueness and potential of this medical innovation.
HOPE Therapeutics, Inc., a subsidiary wholly owned by NRx, is slated to market HTX-100. Dr. Jonathan Javitt, Founder, Chairman, and Chief Scientist at NRx Pharmaceuticals, highlighted the historical context of IV Ketamine, noting its original development for battlefield applications in the 1960s and the lack of significant advancements since. The new formulation, combined with Nephron’s manufacturing expertise, signals a promising shift towards modernizing ketamine therapy for contemporary medical use.
Dr. Javitt also emphasized the transformative potential of HTX-100’s subcutaneous administration, facilitated by advancements in insulin pump technology. This could allow for real-time monitoring and adjustment of ketamine therapy based on individual patient responses, further personalizing and enhancing the effectiveness of treatment.
This development not only signifies a less invasive and more patient-friendly approach to ketamine therapy but also represents an important step forward in the outpatient management of conditions treated with ketamine, potentially broadening its applicability and ease of use in the healthcare industry.
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